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Fat sea has a mild diarrhea effect. Its mechanism is that the increase of intestinal contents after taking fat sea orally can produce mechanical stimulation, which results in the occurrence of diarrhea caused by the increase of reflex intestinal peristalsis. For anesthetized dogs, the intestinal peristalsis can be significantly increased by soaking fat sea overseas cortex, soft shell and kernels separately. This effect can be antagonized by atropine. Rabbit intestinal peristalsis in vitro was increased by the extract of benevolence, but the effect of outer skin and soft shell was not obvious.